IN-SILICO MOLECULAR MODELLING, MM/GBSA BINDING FREE ENERGY AND MOLECULAR DYNAMICS SIMULATION STUDY OF NOVEL PYRIDO FUSED IMIDAZO[4,5-C]QUINOLINES AS POTENTIAL ANTI-TUMOR AGENTS

With an alarming increase in the number of cancer patients and florida gators swimming apparel a variety of tumors, it is high time for intensive investigation on more efficient and potent anti-tumor agents.Though numerous agents have enriched the literature, still there exist challenges, with the availability of different targets and possible cros

The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation.RB has been extensively studied, but its mechanisms of action in normal and cancer cells remain only partly understood.Here, we describe a new mouse model

Cooperative Multi-Agent Reinforcement Learning (MARL) focuses on developing strategies to effectively train multiple agents to learn and adapt policies collaboratively.Despite being a relatively new area of research, most MARL methods are based on well-established approaches used in single-agent deep learning tasks due to their proven effectiveness

After the discovery of an archive document regarding an underground crypt beneath the floors of the Church of St.Margaret (Sv.Marjeta) in Dol pri Ljubljani, Slovenia, further research was carried out to confirm its presence.An area filled with construction waste was discovered during a recent small-scale renovation of the church floor.This finding